CVT-301 to Lead Parkinson's Disease Drug Market by 2022 Finds New Report

New Report Finds Pipeline Agents Aim to Address Unmet Needs of Advanced Patients in Limiting OFF Time

Most of the late-stage pipeline agents are set to meet the needs of advanced patients, with five agents expected to launch during the forecast period (Rytary, CVT-301, opicapone, safinamide, and tozadenant); three of them will be used almost exclusively in advanced patients (CVT-301, opicapone, tozadenant). Additional launches of currently marketed drugs in specific markets will include Duodopa in the US and Japan; Neupro in the US, Japan, and Brazil; Nouriast in the US, 5EU, and Japan; Apokyn in Japan; and Requip XL in Japan. GlobalData believes that Newron's safinamide, Impax's Rytary for early and advanced patients and Civitas' CVT-301 for advanced patients are most promising.

Newron and Zambon’s dual-mechanism MAO-B and glutamate release inhibitor, safinamide, is expected to be a strong competitor in the Parkinson's disease market for early and advanced-stage Parkinson's disease patients, with forecast global sales of $423.2m in 2022. Safinamide is likely to be prescribed over MAO-B inhibitor Azilect (Teva/Lundbeck), due to novel activity as a glutamate release inhibitor.

Impax's Rytary is a slow-release formulation of levodopa that has shown good efficacy and improvements in QOL during clinical trials. Impax is currently finalizing regulatory issues and seeking a new partner for Rytary's ongoing clinical development. In all, the pipeline candidate is forecast to generate sales of $205.3m by 2022, following a late 2014 launch in the US.

Civitas' CVT-301 is a novel reformulation of levodopa and the first inhaled device for Parkinson's disease. It is expected to be the first widely used emergency therapy to meet a key unmet need in wearing-off. Forecast to garner strong sales of $460.1m in 2022, Civitas will likely require partnership for the marketing and sales of its product.

UCB/Biotie's tozadenant is expected to be the second-to-market A2A antagonist that will be used to treat advanced patients, despite limited efficacy in Phase II trials. As a strong player in the Parkinson's disease market, owing to UCB's longstanding presence in the US market and extensive portfolio for Parkinson's disease, tozadenant is forecast to generate global sales of $29.9m in 2022.

Know More About This “Global Drug Forecast and Market Analysis to 2022” Report: http://mrr.cm/ZQd  

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